Prayer is the first say

When leaving for a trip, whether by airplane, car, boat, or other transportation, Muslims say a prayer (du'a) to honor Allah and ask Allah to protect them on the journey.

Arabic Transliteration

Bismi-Allahi wa al-hamdu li-Allahi. Subhana-alladhi sakh-khara la-na hadha wa ma kunna la-hu muqrinin. Wa inna ila Rabbi-na la munqalibun.

Meaning

In the name of Allah, and Praise be to Allah. Glory unto Him Who created this transportation, for us, though we were unable to create it on our own. And unto our Lord we shall return.